| Host: | Rabbit |
| Applications: | WB/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LSM4 |
| Gene ID: | 25804 |
| Uniprot ID: | LSM4_HUMAN |
| Immunogen Region: | 1-139 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-139 of human LSM4 (NP_036453.1). |
| Immunogen Sequence: | MLPLSLLKTAQNHPMLVELK NGETYNGHLVSCDNWMNINL REVICTSRDGDKFWRMPECY IRGSTIKYLRIPDEIIDMVK EEVVAKGRGRGGLQQQKQQK GRGMGGAGRGVFGGRGRGGI PGTGRGQPEKKPGRQAGKQ |
| Function | Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. |
| Protein Name | U6 Snrna-Associated Sm-Like Protein Lsm4Glycine-Rich ProteinGrp |
| Database Links | Reactome: R-HSA-430039Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-U6 Snrna-Associated Sm-Like Protein Lsm4 antibodyAnti-Glycine-Rich Protein antibodyAnti-Grp antibodyAnti-LSM4 antibody |
Information sourced from Uniprot.org