| Tissue Specificity | Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). |
| Post Translational Modifications | Ubiquitinated.undergoes 'Lys-48'-linked polyubiquitination leading to proteasomal degradation. Ubiquitination occurs within the WD repeats at the end of the G1 phase. Ubiquitination may be catalyzed by the CUL4-DDB1 E3 ubiquitin-protein ligase complex and other E3 ligases. |
| Function | Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. |
| Protein Name | Leucine-Rich Repeat And Wd Repeat-Containing Protein 1Centromere Protein 33Cenp-33Origin Recognition Complex-Associated ProteinOrc-Associated ProteinOrca |
| Database Links | |
| Cellular Localisation | NucleusChromosomeCentromereTelomereCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeKinetochoreLocalizes To Heterochromatin During G1 PhaseRestricted To Centromeres Or Telomeres As Cells Progress Though S PhaseWhen Cells Enter MitosisRelocalizes To CentromeresRecruitment To Pericentric Heterochromatin Largely Depends On The Presence Of H3k9me3 |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat And Wd Repeat-Containing Protein 1 antibodyAnti-Centromere Protein 33 antibodyAnti-Cenp-33 antibodyAnti-Origin Recognition Complex-Associated Protein antibodyAnti-Orc-Associated Protein antibodyAnti-Orca antibodyAnti-LRWD1 antibodyAnti-CENP-33 antibodyAnti-ORCA antibody |
Information sourced from Uniprot.org
