| Short Description : | Rabbit polyclonal LRRFIP2 (150-340) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRRFIP2 |
| Gene ID: | 9209 |
| Uniprot ID: | LRRF2_HUMAN |
| Immunogen Region: | 150-340 |
| Immunogen Sequence: | VIEEQEEQMAEFYRENEEKS KELERQKHMCSVLQHKMEEL KEGLRQRDELIEKHGLVIIP DGTPNGDVSHEPVAGAITVV SQEAAQVLESAGEGPLDVRL RKLAGEKEELLSQIRKLKLQ LEEERQKCSRNDGTVGDLAG LQNGSDLQFIEMQRDANRQI SEYKFKLSKAEQDITTLEQS ISRLEGQVLRY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 150-340 of human LRRFIP2 (NP_060194.1). |
| Tissue Specificity | Widely expressed, with highest levels in heart and skeletal muscle. |
| Post Translational Modifications | Ser-190 and Ser-202 are phosphorylated in response to LPS stimulation. Ser-202 phosphorylation regulates the LPS-induced interaction with MYD88. |
| Function | May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
| Protein Name | Leucine-Rich Repeat Flightless-Interacting Protein 2Lrr Flii-Interacting Protein 2 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Flightless-Interacting Protein 2 antibodyAnti-Lrr Flii-Interacting Protein 2 antibodyAnti-LRRFIP2 antibody |
Information sourced from Uniprot.org
