| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-Leucine-rich repeat flightless-interacting protein 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | 4F3-D8-C9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRRFIP1 |
| Gene ID: | 9208 |
| Uniprot ID: | LRRF1_HUMAN |
| Specificity: | This antibody detects endogenous levels of LRRFIP1 and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human LRRFIP1 protein fragments expressed in E.coli. |
| Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
| Protein Name | Leucine-Rich Repeat Flightless-Interacting Protein 1Lrr Flii-Interacting Protein 1Gc-Binding Factor 2Tar Rna-Interacting Protein |
| Database Links | Reactome: R-HSA-1839117Reactome: R-HSA-3134973Reactome: R-HSA-5655302 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Flightless-Interacting Protein 1 antibodyAnti-Lrr Flii-Interacting Protein 1 antibodyAnti-Gc-Binding Factor 2 antibodyAnti-Tar Rna-Interacting Protein antibodyAnti-LRRFIP1 antibodyAnti-GCF2 antibodyAnti-TRIP antibody |
Information sourced from Uniprot.org
