Anti-LRRC14 antibody (1-280) (STJ11102841)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LRRC14 (1-280) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRRC14 |
| Gene ID | 9684 |
| Uniprot ID | LRC14_HUMAN |
| Immunogen Region | 1-280 |
| Immunogen Sequence | MHTLVFLSTRQVLQCQPAAC QALPLLPRELFPLLFKVAFM DKKTVVLRELVHTWPFPLLS FQQLLQECAHCSRALLQERP STESMQAVILGLTARLHTSE PGASTQPLCRKHALRVLDMT GLLDDGVEQDPGTMSMWDCT AAVARTCIAQQQGGAAEPGP APIPVEVRVDLRVNRASYAF LREALRSSVGSPLRLCCRDL RAEDLPMRNTVALLQLLDAG CLRRVDLRFNNLGLRGLSV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human LRRC14 (NP_055480.1). |
Additional Info
| Function | Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. |
| Protein Name | Leucine-Rich Repeat-Containing Protein 14 |
| Database Links | Reactome: R-HSA-9758274 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat-Containing Protein 14 antibodyAnti-LRRC14 antibodyAnti-KIAA0014 antibody |
Information sourced from Uniprot.org