| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LRP1 (4401-4500) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LRP1 |
| Gene ID: |
4035 |
| Uniprot ID: |
LRP1_HUMAN |
| Immunogen Region: |
4401-4500 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4500 of LRP1 (NP_002323.2). |
| Immunogen Sequence: |
PHMTGPRCEEHVFSQQQPGH IASILIPLLLLLLLVLVAGV VFWYKRRVQGAKGFQHQRMT NGAMNVEIGNPTYKMYEGGE PDDVGGLLDADFALDPDKPT |
| Tissue Specificity | Most abundant in liver, brain and lung. |
| Post Translational Modifications | Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1. |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. |
| Protein Name | Prolow-Density Lipoprotein Receptor-Related Protein 1Lrp-1Alpha-2-Macroglobulin ReceptorA2mrApolipoprotein E ReceptorApoerCd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda SubunitLrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda SubunitLrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular DomainLrpicd |
| Database Links | Reactome: R-HSA-2168880Reactome: R-HSA-975634 |
| Cellular Localisation | Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell MembraneSingle-Pass Type I Membrane ProteinMembraneCoated PitLow-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell MembranePeripheral Membrane ProteinExtracellular SideLow-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: CytoplasmNucleusAfter CleavageThe Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The NucleusGolgi OutpostCytoplasmCytoskeletonMicrotubule Organizing CenterLocalizes To The Postsynaptic Golgi Apparatus RegionAlso Named Golgi OutpostWhich Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation |
| Alternative Antibody Names | Anti-Prolow-Density Lipoprotein Receptor-Related Protein 1 antibodyAnti-Lrp-1 antibodyAnti-Alpha-2-Macroglobulin Receptor antibodyAnti-A2mr antibodyAnti-Apolipoprotein E Receptor antibodyAnti-Apoer antibodyAnti-Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit antibodyAnti-Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit antibodyAnti-Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain antibodyAnti-Lrpicd antibodyAnti-LRP1 antibodyAnti-A2MR antibodyAnti-APR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
