| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRP1 |
| Gene ID: | 4035 |
| Uniprot ID: | LRP1_HUMAN |
| Immunogen Region: | 20-168 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-168 of LRP1 (NP_002323.2). |
| Immunogen Sequence: | AIDAPKTCSPKQFACRDQIT CISKGWRCDGERDCPDGSDE APEICPQSKAQRCQPNEHNC LGTELCVPMSRLCNGVQDCM DGSDEGPHCRELQGNCSRLG CQHHCVPTLDGPTCYCNSSF QLQADGKTCKDFDECSVYGT CSQLCTNTD |
| Tissue Specificity | Most abundant in liver, brain and lung. |
| Post Translational Modifications | Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1. |
| Function | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts also as a receptor for IGFBP3 to mediate cell growth inhibition. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. |
| Protein Name | Prolow-Density Lipoprotein Receptor-Related Protein 1 Lrp-1 Alpha-2-Macroglobulin Receptor A2mr Apolipoprotein E Receptor Apoer Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain Lrpicd |
| Database Links | Reactome: R-HSA-2168880 Reactome: R-HSA-975634 |
| Cellular Localisation | Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell Membrane Single-Pass Type I Membrane Protein Membrane Coated Pit Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell Membrane Peripheral Membrane Protein Extracellular Side Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: Cytoplasm Nucleus After Cleavage The Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The Nucleus Golgi Outpost Cytoplasm Cytoskeleton Microtubule Organizing Center Localizes To The Postsynaptic Golgi Apparatus Region Also Named Golgi Outpost Which Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation |
| Alternative Antibody Names | Anti-Prolow-Density Lipoprotein Receptor-Related Protein 1 antibody Anti-Lrp-1 antibody Anti-Alpha-2-Macroglobulin Receptor antibody Anti-A2mr antibody Anti-Apolipoprotein E Receptor antibody Anti-Apoer antibody Anti-Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit antibody Anti-Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit antibody Anti-Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain antibody Anti-Lrpicd antibody Anti-LRP1 antibody Anti-A2MR antibody Anti-APR antibody |
Information sourced from Uniprot.org