Anti-LPXN antibody (STJA0008152)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human LPXN
General Information
| Short Description | Rabbit polyclonal anti-Leupaxin for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LPXN |
| Gene ID | 9404 |
| Uniprot ID | LPXN_HUMAN |
| Immunogen | Synthesized peptide derived from human LPXN |
| Specificity | This antibody detects endogenous levels of LPXN at Human, Mouse |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72. |
| Function | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. |
| Protein Name | Leupaxin |
| Database Links | |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionNucleusPerinuclear RegionCell ProjectionPodosomeCell MembraneShuttles Between The Cytoplasm And NucleusRecruited To The Cell Membrane Following B-Cell Antigen Receptor (Bcr) Cross-Linking In B-CellsEnhanced Focal Adhesion Kinase Activity (Ptk2/Fak) Attenuates Its Nuclear Accumulation And Limits Its Ability To Enhance Serum Response Factor (Srf)-Dependent Gene TranscriptionTargeting To Focal Adhesions Is Essential For Its Tyrosine Phosphorylation In Response To Bombesin |
| Alternative Antibody Names | Anti-Leupaxin antibodyAnti-LPXN antibodyAnti-LDLP antibody |
Information sourced from Uniprot.org