| Post Translational Modifications | Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72. |
| Function | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. |
| Protein Name | Leupaxin |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionNucleusPerinuclear RegionCell ProjectionPodosomeCell MembraneShuttles Between The Cytoplasm And NucleusRecruited To The Cell Membrane Following B-Cell Antigen Receptor (Bcr) Cross-Linking In B-CellsEnhanced Focal Adhesion Kinase Activity (Ptk2/Fak) Attenuates Its Nuclear Accumulation And Limits Its Ability To Enhance Serum Response Factor (Srf)-Dependent Gene TranscriptionTargeting To Focal Adhesions Is Essential For Its Tyrosine Phosphorylation In Response To Bombesin |
| Alternative Antibody Names | Anti-Leupaxin antibodyAnti-LPXN antibodyAnti-LDLP antibody |
Information sourced from Uniprot.org
