| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Leupaxin is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LPXN |
| Gene ID: |
9404 |
| Uniprot ID: |
LPXN_HUMAN |
| Specificity: |
This antibody detects endogenous levels of LPXN at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human LPXN |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72. |
| Function | Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. |
| Protein Name | Leupaxin |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionNucleusPerinuclear RegionCell ProjectionPodosomeCell MembraneShuttles Between The Cytoplasm And NucleusRecruited To The Cell Membrane Following B-Cell Antigen Receptor (Bcr) Cross-Linking In B-CellsEnhanced Focal Adhesion Kinase Activity (Ptk2/Fak) Attenuates Its Nuclear Accumulation And Limits Its Ability To Enhance Serum Response Factor (Srf)-Dependent Gene TranscriptionTargeting To Focal Adhesions Is Essential For Its Tyrosine Phosphorylation In Response To Bombesin |
| Alternative Antibody Names | Anti-Leupaxin antibodyAnti-LPXN antibodyAnti-LDLP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
