| Short Description : | Rabbit polyclonal LPIN2 (180-400) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LPIN2 |
| Gene ID: | 9663 |
| Uniprot ID: | LPIN2_HUMAN |
| Immunogen Region: | 180-400 |
| Immunogen Sequence: | TCDVGVSSDDDKGAQAARGS SNASLKEEECKEPLLFHSGD HYPLSDGDWSPLETTYPQTA CPKSDSELEVKPAESLLRSE SHMEWTWGGFPESTKVSKRE RSDHHPRTATITPSENTHFR VIPSEDNLISEVEKDASMED TVCTIVKPKPRALGTQMSDP TSVAELLEPPLESTQISSML DADHLPNAALAEAPSESKPA AKVDSPSKKKGVHKRSQHQG P |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1). |
| Tissue Specificity | Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. |
| Function | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the endoplasmic reticulum membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Also acts as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. |
| Protein Name | Phosphatidate Phosphatase Lpin2Lipin-2 |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-1483213Reactome: R-HSA-4419969Reactome: R-HSA-75109 |
| Cellular Localisation | NucleusCytoplasmCytosolEndoplasmic Reticulum MembraneTranslocates To Endoplasmic Reticulum Membrane With Increasing Levels Of Oleate |
| Alternative Antibody Names | Anti-Phosphatidate Phosphatase Lpin2 antibodyAnti-Lipin-2 antibodyAnti-LPIN2 antibodyAnti-KIAA0249 antibody |
Information sourced from Uniprot.org
