| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LPIN2 (180-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LPIN2 |
| Gene ID: |
9663 |
| Uniprot ID: |
LPIN2_HUMAN |
| Immunogen Region: |
180-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1). |
| Immunogen Sequence: |
TCDVGVSSDDDKGAQAARGS SNASLKEEECKEPLLFHSGD HYPLSDGDWSPLETTYPQTA CPKSDSELEVKPAESLLRSE SHMEWTWGGFPESTKVSKRE RSDHHPRTATITPSENTHFR VIPSEDNLISEVEKDASMED TVCTIVKPKPRALGTQMSDP TSVAELLEPPLESTQISSML DADHLPNAALAEAPSESKPA AKVDSPSKKKGVHKRSQHQG P |
| Tissue Specificity | Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. |
| Function | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. |
| Protein Name | Phosphatidate Phosphatase Lpin2Lipin-2 |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-1483213Reactome: R-HSA-4419969Reactome: R-HSA-75109 |
| Cellular Localisation | NucleusCytoplasmCytosolEndoplasmic Reticulum MembraneTranslocates To Endoplasmic Reticulum Membrane With Increasing Levels Of Oleate |
| Alternative Antibody Names | Anti-Phosphatidate Phosphatase Lpin2 antibodyAnti-Lipin-2 antibodyAnti-LPIN2 antibodyAnti-KIAA0249 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
