| Host: |
Rabbit |
| Applications: |
CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LOXL1 (570-607) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Formulation: |
Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: |
Affinity Purified |
| Concentration: |
0.66 µg/µl |
| Dilution Range: |
WB: 1:500-1:1, 000ELISA: 1:20, 000-1:50, 000IHC: 1:50IF: 1:50 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Loxl1 |
| Gene ID: |
16949 |
| Uniprot ID: |
LOXL1_MOUSE |
| Immunogen Region: |
570-607 |
| Immunogen: |
Synthetic peptide taken within amino acid region 570-607 on rat LOXL1 protein. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytic proccessing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. Essential for the elastic fiber homeostasis and for their maintenance at adult age. |
| Protein Name | Lysyl Oxidase Homolog 1Lysyl Oxidase 2Lysyl Oxidase-Like Protein 1 |
| Database Links | Reactome: R-MMU-1566948Reactome: -MMU-2243919 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Lysyl Oxidase Homolog 1 antibodyAnti-Lysyl Oxidase 2 antibodyAnti-Lysyl Oxidase-Like Protein 1 antibodyAnti-Loxl1 antibodyAnti-Lox2 antibodyAnti-Loxl antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
