Anti-LNX1 antibody (527-577) (STJA0006514)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human LNX1 AA range: 527-577
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase LNX (527-577) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LNX1 |
| Gene ID | 84708 |
| Uniprot ID | LNX1_HUMAN |
| Immunogen | Synthesized peptide derived from human LNX1 AA range: 527-577 |
| Immunogen Region | 527-577 |
| Specificity | This antibody detects endogenous levels of human LNX1 |
Additional Info
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. |
| Protein Name | E3 Ubiquitin-Protein Ligase LnxLigand Of Numb-Protein X 1Numb-Binding Protein 1Pdz Domain-Containing Ring Finger Protein 2Ring-Type E3 Ubiquitin Transferase Lnx |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Lnx antibodyAnti-Ligand Of Numb-Protein X 1 antibodyAnti-Numb-Binding Protein 1 antibodyAnti-Pdz Domain-Containing Ring Finger Protein 2 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Lnx antibodyAnti-LNX1 antibodyAnti-LNX antibodyAnti-PDZRN2 antibodyAnti-UNQ574 antibodyAnti-PRO1136 antibody |
Information sourced from Uniprot.org