| Post Translational Modifications | Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex. |
| Function | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. |
| Protein Name | Llgl Scribble Cell Polarity Complex Component 2HglLethal(2 Giant Larvae Protein Homolog 2 |
| Cellular Localisation | CytoplasmLocalized In The Perinuclear Structure And Faintly At The Cell-Cell Contacts Sites In The InterphaseLocalized At The Cell Periphery During MetaphaseCortical Localization In Mitotic CellsFound In The Lateral Region Of Polarized Epithelial Cells |
| Alternative Antibody Names | Anti-Llgl Scribble Cell Polarity Complex Component 2 antibodyAnti-Hgl antibodyAnti-Lethal(2 Giant Larvae Protein Homolog 2 antibodyAnti-LLGL2 antibody |
Information sourced from Uniprot.org
