| Tissue Specificity | Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. |
| Post Translational Modifications | Phosphorylated at least at Ser-663 by PRKCI. |
| Function | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. |
| Protein Name | Lethal(2 Giant Larvae Protein Homolog 1LlglDlg4Hugl-1Human Homolog To The D-Lgl Gene Protein |
| Database Links | |
| Cellular Localisation | Early Endosome MembraneGolgi ApparatusTrans-Golgi Network MembraneGolgi Apparatus MembraneCell ProjectionAxonCytoplasmCytoskeletonLocalized To The Lateral Membrane During The Polarization And Formation Cell-Cell ContactsEnriched In Developing Axons |
| Alternative Antibody Names | Anti-Lethal(2 Giant Larvae Protein Homolog 1 antibodyAnti-Llgl antibodyAnti-Dlg4 antibodyAnti-Hugl-1 antibodyAnti-Human Homolog To The D-Lgl Gene Protein antibodyAnti-LLGL1 antibodyAnti-DLG4 antibodyAnti-HUGL antibodyAnti-HUGL1 antibody |
Information sourced from Uniprot.org
