| Short Description : | Goat polyclonal antibody anti-Lipin 2 (C-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications: | Pep-ELISA/IF/FC |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:8000.IF: Strong expression of the protein seen in the cytoplasm of A431 and U2OS cells. Recommended concentration: 10µg/ml. FC:Flow cytometric analysis of A431 cells. Recommended concentration |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | LPIN2 |
| Gene ID: | 9663 |
| Uniprot ID: | LPIN2_HUMAN |
| Accession Number: | NP_055461.1 |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | CYWRDPIPEVDLDDLS |
| Function | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. |
| Protein Name | Phosphatidate Phosphatase Lpin2Lipin-2 |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-1483213Reactome: R-HSA-4419969Reactome: R-HSA-75109 |
| Cellular Localisation | NucleusCytoplasmCytosolEndoplasmic Reticulum MembraneTranslocates To Endoplasmic Reticulum Membrane With Increasing Levels Of Oleate |
| Alternative Antibody Names | Anti-Phosphatidate Phosphatase Lpin2 antibodyAnti-Lipin-2 antibodyAnti-LPIN2 antibodyAnti-KIAA0249 antibody |
Information sourced from Uniprot.org
