| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LIPC (280-499) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LIPC |
| Gene ID: |
3990 |
| Uniprot ID: |
LIPC_HUMAN |
| Immunogen Region: |
280-499 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 280-499 of human LIPC (NP_000227.2). |
| Immunogen Sequence: |
ERSVHLFIDSLLHAGTQSMA YPCGDMNSFSQGLCLSCKKG RCNTLGYHVRQEPRSKSKRL FLVTRAQSPFKVYHYQFKIQ FINQTETPIQTTFTMSLLGT KEKMQKIPITLGKGIASNKT YSFLITLDVDIGELIMIKFK WENSAVWANVWDTVQTIIPW STGPRHSGLVLKTIRVKAGE TQQRMTFCSENTDDLLLRPT QEKIFVKCEIKSKTSKRKIR |
| Function | Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position. |
| Protein Name | Hepatic Triacylglycerol LipaseHlHepatic LipaseLipase Member CLysophospholipasePhospholipase A1 |
| Database Links | Reactome: R-HSA-8963889Reactome: R-HSA-8964026 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Hepatic Triacylglycerol Lipase antibodyAnti-Hl antibodyAnti-Hepatic Lipase antibodyAnti-Lipase Member C antibodyAnti-Lysophospholipase antibodyAnti-Phospholipase A1 antibodyAnti-LIPC antibodyAnti-HTGL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
