Anti-LINE 1 ORF1p antibody [R02-2H1] (STJA0035254)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human LINE-1 ORF1p
General Information
| Short Description | Rabbit monoclonal anti-LINE 1 ORF1p for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-2H1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | L1RE1Uniprot ID=LORF1_HUMAN" |
| Immunogen | Recombinant protein of human LINE-1 ORF1p |
Additional Info
| Post Translational Modifications | Polyubiquitinated, probably by UBR2, which induces its degradation. |
| Function | Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. |
| Protein Name | Line-1 Retrotransposable Element Orf1 ProteinL1orf1pLine Retrotransposable Element 1Line1 Retrotransposable Element 1 |
| Cellular Localisation | NucleusNucleolusCytoplasmCytoplasmic Ribonucleoprotein GranuleStress GranuleColocalizes With Its Encoding Rna In Cytoplasmic Ribonucleoprotein ParticleMainly CytoplasmicRarely Detected In The NucleusPossibly Within The Nucleolus |
| Alternative Antibody Names | Anti-Line-1 Retrotransposable Element Orf1 Protein antibodyAnti-L1orf1p antibodyAnti-Line Retrotransposable Element 1 antibodyAnti-Line1 Retrotransposable Element 1 antibodyAnti-L1RE1 antibodyAnti-LRE1 antibody |
Information sourced from Uniprot.org