Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | LIMS1 |
Gene ID: | 3987 |
Uniprot ID: | LIMS1_HUMAN |
Immunogen Region: | 1-325 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human LIMS1 (NP_001180417.1). |
Immunogen Sequence: | MANALASATCERCKGGFAPA EKIVNSNGELYHEQCFVCAQ CFQQFPEGLFYEFEGRKYCE HDFQMLFAPCCHQCGEFIIG RVIKAMNNSWHPECFRCDLC QEVLADIGFVKNAGRHLCRP CHNREKARGLGKYICQKCHA IIDEQPLIFKNDPYHPDHFN CANCGKELTADARELKGELY CLPCHDKMGVPICGACRRPI EGRVVNAMGKQWHVEHFVCA KCEKPFLGHRHYERKGLAY |
Tissue Specificity | Expressed in most tissues except in the brain. |
Function | Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration. |
Protein Name | Lim And Senescent Cell Antigen-Like-Containing Domain Protein 1Particularly Interesting New Cys-His Protein 1Pinch-1Renal Carcinoma Antigen Ny-Ren-48 |
Database Links | Reactome: R-HSA-446353Reactome: R-HSA-446388 |
Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic Side |
Alternative Antibody Names | Anti-Lim And Senescent Cell Antigen-Like-Containing Domain Protein 1 antibodyAnti-Particularly Interesting New Cys-His Protein 1 antibodyAnti-Pinch-1 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-48 antibodyAnti-LIMS1 antibodyAnti-PINCH antibodyAnti-PINCH1 antibody |
Information sourced from Uniprot.org