Anti-LILRB3 antibody (580-631) {Biotin} (STJ501607)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 580-631Β on human LILRB3 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-LILRB3 (580-631) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.74 Β΅g/Β΅l |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:20, 000ELISA: 1:20, 000IP: 1:200IHC: 1:50-1:150 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20Β°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | LILRB3 |
| Gene ID | 102725035/107987462 |
| Uniprot ID | LIRB3_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 580-631Β on human LILRB3 protein. |
| Immunogen Region | 580-631 |
| Specificity | This antibody will detect all three isoforms of human LILRB3 protein. |
Additional Info
| Tissue Specificity | Detected in monocytes and B-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cd85 Antigen-Like Family Member AImmunoglobulin-Like Transcript 5Ilt-5Monocyte Inhibitory Receptor Hl9Cd Antigen Cd85a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibodyAnti-Lir-3 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 3 antibodyAnti-Cd85 Antigen-Like Family Member A antibodyAnti-Immunoglobulin-Like Transcript 5 antibodyAnti-Ilt-5 antibodyAnti-Monocyte Inhibitory Receptor Hl9 antibodyAnti-Cd Antigen Cd85a antibodyAnti-LILRB3 antibodyAnti-ILT5 antibodyAnti-LIR3 antibody |
Information sourced from Uniprot.org