| Host: | Rabbit |
| Applications: | ELISA/IHC/IP/WB |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-LILRB3 (580-631) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.74 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:20, 000 ELISA: 1:20, 000 IP: 1:200 IHC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | LILRB3 |
| Gene ID: | 102725035/107987462 |
| Uniprot ID: | LIRB3_HUMAN |
| Immunogen Region: | 580-631 |
| Specificity: | This antibody will detect all three isoforms of human LILRB3 protein. |
| Immunogen: | Synthetic peptide taken within amino acid region 580-631 on human LILRB3 protein. |
| Tissue Specificity | Detected in monocytes and B-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 Lir-3 Leukocyte Immunoglobulin-Like Receptor 3 Cd85 Antigen-Like Family Member A Immunoglobulin-Like Transcript 5 Ilt-5 Monocyte Inhibitory Receptor Hl9 Cd Antigen Cd85a |
| Database Links | Reactome: R-HSA-198933 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibody Anti-Lir-3 antibody Anti-Leukocyte Immunoglobulin-Like Receptor 3 antibody Anti-Cd85 Antigen-Like Family Member A antibody Anti-Immunoglobulin-Like Transcript 5 antibody Anti-Ilt-5 antibody Anti-Monocyte Inhibitory Receptor Hl9 antibody Anti-Cd Antigen Cd85a antibody Anti-LILRB3 antibody Anti-ILT5 antibody Anti-LIR3 antibody |
Information sourced from Uniprot.org