| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LILRB3 (400-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LILRB3 |
| Gene ID: |
102725035/107987462 |
| Uniprot ID: |
LIRB3_HUMAN |
| Immunogen Region: |
400-500 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human LILRB3 (NP_001307889.1). |
| Immunogen Sequence: |
RSSNPHLLSFPSEPLELMVS GHSGGSSLPPTGPPSTPGGP EDQPLNPPGSGPQNGLGRYL EVLIGVSVAFVLLLFLLLFL LLLRQRHSKHRTSDQRKTDF Q |
| Tissue Specificity | Detected in monocytes and B-cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cd85 Antigen-Like Family Member AImmunoglobulin-Like Transcript 5Ilt-5Monocyte Inhibitory Receptor Hl9Cd Antigen Cd85a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibodyAnti-Lir-3 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 3 antibodyAnti-Cd85 Antigen-Like Family Member A antibodyAnti-Immunoglobulin-Like Transcript 5 antibodyAnti-Ilt-5 antibodyAnti-Monocyte Inhibitory Receptor Hl9 antibodyAnti-Cd Antigen Cd85a antibodyAnti-LILRB3 antibodyAnti-ILT5 antibodyAnti-LIR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
