Western blot analysis of lysates from Jurkat cells, using LILRB3 Rabbit polyclonal antibody (STJ118543) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-LILRB3 antibody (400-500) (STJ118543)

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STJ118543
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LILRB3
Gene ID: 102725035/107987462
Uniprot ID: LIRB3_HUMAN
Immunogen Region: 400-500
Specificity: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human LILRB3 (NP_001307889.1).
Immunogen Sequence: RSSNPHLLSFPSEPLELMVS GHSGGSSLPPTGPPSTPGGP EDQPLNPPGSGPQNGLGRYL EVLIGVSVAFVLLLFLLLFL LLLRQRHSKHRTSDQRKTDF Q
Tissue Specificity Detected in monocytes and B-cells.
Post Translational Modifications Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.
Function May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3
Lir-3
Leukocyte Immunoglobulin-Like Receptor 3
Cd85 Antigen-Like Family Member A
Immunoglobulin-Like Transcript 5
Ilt-5
Monocyte Inhibitory Receptor Hl9
Cd Antigen Cd85a
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibody
Anti-Lir-3 antibody
Anti-Leukocyte Immunoglobulin-Like Receptor 3 antibody
Anti-Cd85 Antigen-Like Family Member A antibody
Anti-Immunoglobulin-Like Transcript 5 antibody
Anti-Ilt-5 antibody
Anti-Monocyte Inhibitory Receptor Hl9 antibody
Anti-Cd Antigen Cd85a antibody
Anti-LILRB3 antibody
Anti-ILT5 antibody
Anti-LIR3 antibody

Information sourced from Uniprot.org

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