Anti-LIG3 antibody (254-460) (STJ115468)

Name: Anti-LIG3 antibody (254-460) (STJ115468)
SKU: STJ115468
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ115468

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Short Description	Rabbit polyclonal LIG3 (254-460) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	LIG3
Gene ID	3980
Uniprot ID	DNLI3_HUMAN
Immunogen Region	254-460
Immunogen Sequence	CDPRHKDCLLREFRKLCAMV ADNPSYNTKTQIIQDFLRKG SAGDGFHGDVYLTVKLLLPG VIKTVYNLNDKQIVKLFSRI FNCNPDDMARDLEQGDVSET IRVFFEQSKSFPPAAKSLLT IQEVDEFLLRLSKLTKEDEQ QQALQDIASRCTANDLKCII RLIKHDLKMNSGAKHVLDAL DPNAYEAFKASRNLQDVVER VLHNAQE
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 254-460 of human DNA Ligase III/LIG3 (NP_039269.2).

Tissue Specificity	Testis, thymus, prostate and heart.
Function	Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair.
Protein Name	Dna Ligase 3 Dna Ligase Iii Polydeoxyribonucleotide Synthase Atp 3
Database Links	Reactome: R-HSA-110381 Reactome: R-HSA-5649702 Reactome: R-HSA-5685939 Reactome: R-HSA-5696397 Reactome: R-HSA-6782210 Reactome: R-HSA-9913635 P49916-1
Cellular Localisation	Isoform 1: Mitochondrion Contains An N-Terminal Mitochondrial Transit Peptide Isoform 2: Mitochondrion Isoform 3: Nucleus Lacks The N-Terminal Mitochondrial Transit Peptide Isoform 4: Nucleus
Alternative Antibody Names	Anti-Dna Ligase 3 antibody Anti-Dna Ligase Iii antibody Anti-Polydeoxyribonucleotide Synthase Atp 3 antibody Anti-LIG3 antibody

Information sourced from Uniprot.org