| Short Description : | Mouse monoclonal anti-LH for use in LF, CLIA and FIA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | LF/CLIA/FIA |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 5304 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Concentration: | 5.0 mg/ml (+/-10 %) |
| Formulation: | 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Storage Instruction: | Store at 2–8 °C, and do not freeze. |
| Immunogen: | Beta 1 as described in Nilsson et al. (2001) NA Two antibodies binding to the same, or closely located epitopes, belong to the same group and hence cannot be used as a pair in a sandwich assay. Epitope group numbering does not give any detailed infor |
| Specificity: | Antibody recognizes human luteinizing hormone (lutropin) , and its beta-subunit. LH 100 %, LH a 8 %, LH ß 108 %, FSH 1 %, hCG |
| Background | In both males and females, LH is essential for reproduction. In females FSH initiates follicular growth and at the time of the maturation of the follicle the estrogen rise leads to a release of LH over a 24–48 hour period. This LH surge triggers ovulation thereby not only releasing the egg, but also initiating the conversion of the residual follicle into a corpus luteum that, in turn, produces progesterone to prepare the endometrium for a possible implantation. LH is necessary to maintain luteal function for the first two weeks. In case of a pregnancy luteal function will be further maintained by the action of hCG from the newly established pregnancy. In the male, LH acts upon the Leydig cells of the testis and is responsible for the production of testosterone. |
Information sourced from Uniprot.org
