Anti-LGR6 antibody (801-900) [S9MR] (STJ11102429)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal GPCR/LGR6 (801-900) antibody for use in WB, IF, ICC and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S9MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LGR6 |
| Gene ID | 59352 |
| Uniprot ID | LGR6_HUMAN |
| Immunogen Region | 801-900 |
| Immunogen Sequence | FPVTPEAVKSVLLVVLPLPA CLNPLLYLLFNPHFRDDLRR LRPRAGDSGPLAYAAAGELE KSSCDSTQALVAFSDVDLIL EASEAGRPPGLETYGFPSVT |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 801-900 of human LGR6 (Q9HBX8). |
Additional Info
| Function | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. |
| Protein Name | Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 |
| Database Links | Reactome: R-HSA-4641263 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 6 antibodyAnti-LGR6 antibodyAnti-UNQ6427 antibodyAnti-PRO21331 antibodyAnti-VTS20631 antibody |
Information sourced from Uniprot.org