| Host: |
Mouse |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Galectin-3 (200-300 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ABT-GAL3 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2bk |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:50-500WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LGALS3 |
| Gene ID: |
3958 |
| Uniprot ID: |
LEG3_HUMAN |
| Immunogen Region: |
200-300 aa |
| Specificity: |
This antibody detects endogenous levels of human Galectin 3, TRIS-EDTA of pH9.0 was used for Heat-induced epitope retrieval (HIER) |
| Immunogen: |
Synthesized peptide derived from the human Galectin 3 at the amino acid range 200-300 |
| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. |
| Protein Name | Galectin-3Gal-335 Kda LectinCarbohydrate-Binding Protein 35Cbp 35Galactose-Specific Lectin 3Galactoside-Binding ProteinGalbpIge-Binding ProteinL-31Laminin-Binding ProteinLectin L-29Mac-2 Antigen |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-879415Reactome: R-HSA-8939246Reactome: R-HSA-8941333 |
| Cellular Localisation | CytoplasmNucleusSecretedSecreted By A Non-Classical Secretory Pathway And Associates With The Cell SurfaceCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Galectin-3 antibodyAnti-Gal-3 antibodyAnti-35 Kda Lectin antibodyAnti-Carbohydrate-Binding Protein 35 antibodyAnti-Cbp 35 antibodyAnti-Galactose-Specific Lectin 3 antibodyAnti-Galactoside-Binding Protein antibodyAnti-Galbp antibodyAnti-Ige-Binding Protein antibodyAnti-L-31 antibodyAnti-Laminin-Binding Protein antibodyAnti-Lectin L-29 antibodyAnti-Mac-2 Antigen antibodyAnti-LGALS3 antibodyAnti-MAC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
