| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LGALS3 (1-250) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LGALS3 |
| Gene ID: |
3958 |
| Uniprot ID: |
LEG3_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human Galectin 3/Galectin 3/LGALS3 (NP_002297.2). |
| Immunogen Sequence: |
MADNFSLHDALSGSGNPNPQ GWPGAWGNQPAGAGGYPGAS YPGAYPGQAPPGAYPGQAPP GAYPGAPGAYPGAPAPGVYP GPPSGPGAYPSSGQPSATGA YPATGPYGAPAGPLIVPYNL PLPGGVVPRMLITILGTVKP NANRIALDFQRGNDVAFHFN PRFNENNRRVIVCNTKLDNN WGREERQSVFPFESGKPFKI QVLVEPDHFKVAVNDAHLLQ YNHRVKKLNEISKLGISGD |
| Tissue Specificity | A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. |
| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. |
| Protein Name | Galectin-3Gal-335 Kda LectinCarbohydrate-Binding Protein 35Cbp 35Galactose-Specific Lectin 3Galactoside-Binding ProteinGalbpIge-Binding ProteinL-31Laminin-Binding ProteinLectin L-29Mac-2 Antigen |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-879415Reactome: R-HSA-8939246Reactome: R-HSA-8941333 |
| Cellular Localisation | CytoplasmNucleusSecretedSecreted By A Non-Classical Secretory Pathway And Associates With The Cell SurfaceCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Galectin-3 antibodyAnti-Gal-3 antibodyAnti-35 Kda Lectin antibodyAnti-Carbohydrate-Binding Protein 35 antibodyAnti-Cbp 35 antibodyAnti-Galactose-Specific Lectin 3 antibodyAnti-Galactoside-Binding Protein antibodyAnti-Galbp antibodyAnti-Ige-Binding Protein antibodyAnti-L-31 antibodyAnti-Laminin-Binding Protein antibodyAnti-Lectin L-29 antibodyAnti-Mac-2 Antigen antibodyAnti-LGALS3 antibodyAnti-MAC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
