| Host: | Rabbit |
| Applications: | WB/IHC-P/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000 IHC-P:1:200-1:800 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirement |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LGALS3 |
| Gene ID: | 3958 |
| Uniprot ID: | LEG3_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Galectin 3/LGALS3 (P17931). |
| Immunogen Sequence: | MADNFSLHDALSGSGNPNPQ GWPGAWGNQPAGAGGYPGAS YPGAYPGQAPPGAYPGQAPP GAYPGAPGAYPGAPAPGVYP GPPSGPGAYPSSGQPSATGA |
| Tissue Specificity | A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes. |
| Function | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. |
| Protein Name | Galectin-3 Gal-3 35 Kda Lectin Carbohydrate-Binding Protein 35 Cbp 35 Galactose-Specific Lectin 3 Galactoside-Binding Protein Galbp Ige-Binding Protein L-31 Laminin-Binding Protein Lectin L-29 Mac-2 Antigen |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-879415 Reactome: R-HSA-8939246 Reactome: R-HSA-8941333 |
| Cellular Localisation | Cytoplasm Nucleus Secreted Secreted By A Non-Classical Secretory Pathway And Associates With The Cell Surface Can Be Secreted The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10 It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Galectin-3 antibody Anti-Gal-3 antibody Anti-35 Kda Lectin antibody Anti-Carbohydrate-Binding Protein 35 antibody Anti-Cbp 35 antibody Anti-Galactose-Specific Lectin 3 antibody Anti-Galactoside-Binding Protein antibody Anti-Galbp antibody Anti-Ige-Binding Protein antibody Anti-L-31 antibody Anti-Laminin-Binding Protein antibody Anti-Lectin L-29 antibody Anti-Mac-2 Antigen antibody Anti-LGALS3 antibody Anti-MAC2 antibody |
Information sourced from Uniprot.org