| Short Description : | Rabbit polyclonal anti-Beta-1, 3-N-acetylglucosaminyltransferase lunatic fringe (121-170 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LFNG |
| Gene ID: | 3955 |
| Uniprot ID: | LFNG_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human LFNG at the amino acid range 121-170 |
| Immunogen Region: | 121-170 aa |
| Specificity: | Lunatic Fringe Polyclonal Antibody detects endogenous levels of Lunatic Fringe protein. |
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. |
| Protein Name | Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic FringeO-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-5083630Reactome: R-HSA-9824272Reactome: R-HSA-9831926 |
| Cellular Localisation | Golgi ApparatusGolgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic Fringe antibodyAnti-O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase antibodyAnti-LFNG antibody |
Information sourced from Uniprot.org
