| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-LAX1 (Internal) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary experiments in lysates of Peripheral Blood Mononucleocytes and of cell lines HeLa and MOLT4 gave no specific signal but low background (at antibody concentration up to 1µg/m |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | LAX1 |
| Gene ID: | 54900 |
| Uniprot ID: | LAX1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_060243.2; NP_001129662.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_060243.2; NP_001129662.1). |
| Immunogen Sequence: | NLTPSAHCINVRAS |
| Post Translational Modifications | Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation.which leads to the recruitment of GRB2, PIK3R1 and GRAP2. |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. |
| Protein Name | Lymphocyte Transmembrane Adapter 1Linker For Activation Of X CellsMembrane-Associated Adapter Protein Lax |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Lymphocyte Transmembrane Adapter 1 antibodyAnti-Linker For Activation Of X Cells antibodyAnti-Membrane-Associated Adapter Protein Lax antibodyAnti-LAX1 antibodyAnti-LAX antibody |
Information sourced from Uniprot.org