| Post Translational Modifications | Autophosphorylated and phosphorylated during M-phase of the cell cycle. Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation. Phosphorylated by MAP4Ks.in parallel to STK3/MST2 and resulting to its activation. Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy. |
| Function | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1. |
| Protein Name | Serine/Threonine-Protein Kinase Lats1Large Tumor Suppressor Homolog 1Warts Protein KinaseH-Warts |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleMidbodySpindle Pole BodyLocalizes To The Centrosomes Throughout Interphase But Migrates To The Mitotic ApparatusIncluding Spindle Pole BodiesMitotic SpindleAnd MidbodyDuring Mitosis |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Lats1 antibodyAnti-Large Tumor Suppressor Homolog 1 antibodyAnti-Warts Protein Kinase antibodyAnti-H-Warts antibodyAnti-LATS1 antibodyAnti-WARTS antibody |
Information sourced from Uniprot.org
