Anti-LAT1 antibody [PT1462R] (STJA0040291)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Large Neutral Amino Acids Transporter Small Subunit 1 for use in WB, IHC, IF, IP and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT1462R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:200-1:1000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000IP 1:50-1:200 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC7A5 |
| Gene ID | 8140 |
| Uniprot ID | LAT1_HUMAN |
| Specificity | Endogenous |
Additional Info
| Function | The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine. The heterodimer with SLC3A2 mediates the uptake of L-DOPA. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier. May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier. Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane. (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. |
| Protein Name | Large Neutral Amino Acids Transporter Small Subunit 14f2 Light Chain4f2 Lc4f2lcCd98 Light ChainIntegral Membrane Protein E16E16L-Type Amino Acid Transporter 1Hlat1Solute Carrier Family 7 Member 5Y+ System Cationic Amino Acid Transporter |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230Reactome: R-HSA-71240 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneLysosome MembraneLocated To The Plasma Membrane By Slc3a2/4f2hcLocalized To The Apical Membrane Of Placental Syncytiotrophoblastic CellsRecruited To Lysosomes By Laptm4b |
| Alternative Antibody Names | Anti-Large Neutral Amino Acids Transporter Small Subunit 1 antibodyAnti-4f2 Light Chain antibodyAnti-4f2 Lc antibodyAnti-4f2lc antibodyAnti-Cd98 Light Chain antibodyAnti-Integral Membrane Protein E16 antibodyAnti-E16 antibodyAnti-L-Type Amino Acid Transporter 1 antibodyAnti-Hlat1 antibodyAnti-Solute Carrier Family 7 Member 5 antibodyAnti-Y+ System Cationic Amino Acid Transporter antibodyAnti-SLC7A5 antibodyAnti-CD98LC antibodyAnti-LAT1 antibodyAnti-MPE16 antibody |
Information sourced from Uniprot.org