Anti-LAMTOR5 antibody (1-173) (STJ29891)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LAMTOR5 (1-173) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LAMTOR5 |
| Gene ID | 10542 |
| Uniprot ID | LTOR5_HUMAN |
| Immunogen Region | 1-173 |
| Immunogen Sequence | MEPGAGHLDGHRAGSPSLRQ ALCDGSAVMFSSKERGRCTV INFVPLEAPLRSTPRSRQVT EACGGEGRAVPLGSEPEWSV GGMEATLEQHLEDTMKNPSI VGVLCTDSQGLNLGCRGTLS DEHAGVISVLAQQAAKLTSD PTDIPVVCLESDNGNIMIQK HDGITVAVHKMAS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human LAMTOR5 (NP_006393.2). |
Additional Info
| Tissue Specificity | Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection. |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. |
| Protein Name | Ragulator Complex Protein Lamtor5Hepatitis B Virus X-Interacting ProteinHbv X-Interacting ProteinHbx-Interacting ProteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | LysosomeCytoplasmCytosol |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor5 antibodyAnti-Hepatitis B Virus X-Interacting Protein antibodyAnti-Hbv X-Interacting Protein antibodyAnti-Hbx-Interacting Protein antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 5 antibodyAnti-LAMTOR5 antibodyAnti-HBXIP antibodyAnti-XIP antibody |
Information sourced from Uniprot.org