| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LAMP1 (208-363) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Lamp1 |
| Gene ID: |
16783 |
| Uniprot ID: |
LAMP1_MOUSE |
| Immunogen Region: |
208-363 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 208-363 of mouse LAMP1 (NP_001304282.1). |
| Immunogen Sequence: |
PTVSKYNVTGNNGTCLLASM ALQLNITYLKKDNKTVTRAF NISPNDTSSGSCGINLVTLK VENKNRALELQFGMNASSSL FFLQGVRLNMTLPDALVPTF SISNHSLKALQATVGNSYKC NTEEHIFVSKMLSLNVFSVQ VQAFKVDSDRFGSVEE |
| Post Translational Modifications | O- and N-glycosylated.some of the N-glycans attached to LAMP-1 are polylactosaminoglycans. |
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. |
| Protein Name | Lysosome-Associated Membrane Glycoprotein 1Lamp-1Lysosome-Associated Membrane Protein 1120 Kda Lysosomal Membrane GlycoproteinCd107 Antigen-Like Family Member ALgp-120Lysosomal Membrane Glycoprotein ALgp-AP2bCd Antigen Cd107a |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneLate Endosome MembraneCell MembraneCytolytic Granule MembraneThis Protein Shuttles Between LysosomesEndosomesAnd The Plasma MembraneColocalizes With Osbpl1a At The Late Endosome |
| Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 1 antibodyAnti-Lamp-1 antibodyAnti-Lysosome-Associated Membrane Protein 1 antibodyAnti-120 Kda Lysosomal Membrane Glycoprotein antibodyAnti-Cd107 Antigen-Like Family Member A antibodyAnti-Lgp-120 antibodyAnti-Lysosomal Membrane Glycoprotein A antibodyAnti-Lgp-A antibodyAnti-P2b antibodyAnti-Cd Antigen Cd107a antibodyAnti-Lamp1 antibodyAnti-Lamp-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of U2OS cells using [KD Validated] LAMP1 Rabbit polyclonal antibody (STJ11104366) at dilution of 1:20 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/177010/368182/STJ11104366_1__89933.1713133691.jpg?c=1 "Immunofluorescence analysis of U2OS cells using [KD Validated] LAMP1 Rabbit polyclonal antibody (STJ11104366) at dilution of 1:20 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
