Anti-Lambda Light Chain antibody [LCN-2] (STJ16101848)

SKU:
STJ16101848-1

£431.50
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Lambda Light Chain is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: LCN-2
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: Bioreactor Concentrate with 0.05% Azide
Purification: Concentrate
Dilution Range: IHC-P 1:200-1:400
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Purified human IgG myeloma proteins coupled to polyaminostyren microbeads
Background This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant. Pretreatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0, or in 50 mM Tris buffer pH9.5, for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections. Note: Dilution of the antibody in 10% normal goat serum followed by a goat anti-mouse secondary antibody-based detection is recommended. Control tissue HEK293T, Tonsil, Spleen

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