Anti-LAMA3 antibody (Internal) (STJ70844)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-LAMA3 (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Preliminary experiments in human kidney, lung and skin lysates gave no specific signal but low background (at antibody concentration up to 1ยตg/ml). We would appreciate any feedback from |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | LAMA3 |
| Gene ID | 3909 |
| Uniprot ID | LAMA3_HUMAN |
| Accession Number | NP_937762.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | NNQCHSSHKRRTK |
| Specificity | This antibody is expected to recognise isoform 1 (NP_937762.1) only. |
Additional Info
| Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. |
| Protein Name | Laminin Subunit Alpha-3Epiligrin 170 Kda SubunitE170Epiligrin Subunit AlphaKalinin Subunit AlphaLaminin-5 Subunit AlphaLaminin-6 Subunit AlphaLaminin-7 Subunit AlphaNicein Subunit Alpha |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022090Reactome: R-HSA-2214320Reactome: R-HSA-3000157Reactome: R-HSA-3000171Reactome: R-HSA-3000178Reactome: R-HSA-446107Reactome: R-HSA-8874081 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMajor Component |
| Alternative Antibody Names | Anti-Laminin Subunit Alpha-3 antibodyAnti-Epiligrin 170 Kda Subunit antibodyAnti-E170 antibodyAnti-Epiligrin Subunit Alpha antibodyAnti-Kalinin Subunit Alpha antibodyAnti-Laminin-5 Subunit Alpha antibodyAnti-Laminin-6 Subunit Alpha antibodyAnti-Laminin-7 Subunit Alpha antibodyAnti-Nicein Subunit Alpha antibodyAnti-LAMA3 antibodyAnti-LAMNA antibody |
Information sourced from Uniprot.org