| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity. Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages. Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface. The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity. Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance. Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR). Does not show laccase activity. |
| Protein Name | Purine Nucleoside Phosphorylase Lacc1Adenosine Deaminase Lacc1Fatty Acid Metabolism-Immunity NexusGuanosine Phosphorylase Lacc1Laccase Domain-Containing Protein 1S-Methyl-5'-Thioadenosine Phosphorylase Lacc1 |
| Cellular Localisation | CytoplasmNucleusEndoplasmic ReticulumPeroxisomeUpon Stimulation Of The Pattern-Recognition Receptor (Prr) Nod2Localizes To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Purine Nucleoside Phosphorylase Lacc1 antibodyAnti-Adenosine Deaminase Lacc1 antibodyAnti-Fatty Acid Metabolism-Immunity Nexus antibodyAnti-Guanosine Phosphorylase Lacc1 antibodyAnti-Laccase Domain-Containing Protein 1 antibodyAnti-S-Methyl-5'-Thioadenosine Phosphorylase Lacc1 antibodyAnti-LACC1 antibodyAnti-C13orf31 antibodyAnti-FAMIN antibody |
Information sourced from Uniprot.org
