| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:4000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | L3MBTL3 |
| Gene ID: | 84456 |
| Uniprot ID: | LMBL3_HUMAN |
| Immunogen Region: | 1-255 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-255 of human L3MBTL3 (NP_115814.1). |
| Immunogen Sequence: | MTESASSTSGQEFDVFSVMD WKDGVGTLPGSDLKFRVNEF GALEVITDENEMENVKKATA TTTWMVPTAQEAPTSPPSSR PVFPPAYWTSPPGCPTVFSE KTGMPFRLKDPVKVEGLQFC ENCCQYGNVDECLSGGNYCS QNCARHIKDKDQKEERDVEE DNEEEDPKCSRKKKPKLSLK ADTKEDGEERDDEMENKQDV RILRGSQRARRKRRGDSAVL KQGLPPKGKKAWCWASYLE |
| Function | Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells. |
| Protein Name | Lethal(3malignant Brain Tumor-Like Protein 3H-L(3mbt-Like Protein 3L(3mbt-Like Protein 3L3mbt-Like 3Mbt-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lethal(3malignant Brain Tumor-Like Protein 3 antibodyAnti-H-L(3mbt-Like Protein 3 antibodyAnti-L(3mbt-Like Protein 3 antibodyAnti-L3mbt-Like 3 antibodyAnti-Mbt-1 antibodyAnti-L3MBTL3 antibodyAnti-KIAA1798 antibodyAnti-MBT1 antibody |
Information sourced from Uniprot.org