• Immunohistochemistry analysis of paraffin-embedded human esophagus epithelium (A) , salivary gland basal cell (B) , lung squamous cell carcinoma (C) , endometrium admosquamous carcinoma (D) , showing cytoplasmic and membrane localization with DAB staining usi
  • Western blot analysis using Cytokeratin 5 monoclonal antibody against truncated CK5 recombinant protein.

Anti-KRT5 antibody [3E2F1] (STJ97989)

SKU:
STJ97989

£139.00 - £336.00
Current Stock:
Host: Mouse
Applications: WB/IHC/IF/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Keratin, type II cytoskeletal 5 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Monoclonal
Clone ID: 3E2F1
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KRT5
Gene ID: 3852
Uniprot ID: K2C5_HUMAN
Specificity: Cytokeratin 5 Monoclonal Antibody detects endogenous levels of Cytokeratin 5 protein.
Immunogen: Purified recombinant fragment of Cytokeratin 5 expressed in E. Coli.
Post Translational Modifications Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle. Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis. CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury. O-glycosylated.
Function Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes.
Protein Name Keratin - Type Ii Cytoskeletal 5
58 Kda Cytokeratin
Cytokeratin-5
Ck-5
Keratin-5
K5
Type-Ii Keratin Kb5
Database Links Reactome: R-HSA-446107
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Keratin - Type Ii Cytoskeletal 5 antibody
Anti-58 Kda Cytokeratin antibody
Anti-Cytokeratin-5 antibody
Anti-Ck-5 antibody
Anti-Keratin-5 antibody
Anti-K5 antibody
Anti-Type-Ii Keratin Kb5 antibody
Anti-KRT5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance