• Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Cytokeratin 17 antibody. The HRP-conjugated anti- mouseIgG antibody was used to detect the antibody. Predicted band size: 48 kDa
  • Human prostate tissue was stained with Anti-Cytokeratin 17 (ABT-CK17) Antibody

Anti-KRT17 antibody (300-432 aa) [ABT-CK17] (STJ196821)

SKU:
STJ196821

£168.00 - £226.00
Current Stock:
Host: Mouse
Applications: IHC/IF/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Keratin, type I cytoskeletal 17 (300-432 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.
Clonality: Monoclonal
Clone ID: ABT-CK17
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-500
WB 1:200-1000
IF 1:100-500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KRT17
Gene ID: 3872
Uniprot ID: K1C17_HUMAN
Immunogen Region: 300-432 aa
Specificity: This antibody detects endogenous levels of human Cytokeratin 17. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section. The antib
Immunogen: Synthesized peptide derived from the human Cytokeratin 17 at the amino acid range 300-432
Post Translational Modifications Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.
Function Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Protein Name Keratin - Type I Cytoskeletal 17
39.1
Cytokeratin-17
Ck-17
Keratin-17
K17
Database Links Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Keratin - Type I Cytoskeletal 17 antibody
Anti-39.1 antibody
Anti-Cytokeratin-17 antibody
Anti-Ck-17 antibody
Anti-Keratin-17 antibody
Anti-K17 antibody
Anti-KRT17 antibody

Information sourced from Uniprot.org

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