| Host: |
Mouse |
| Applications: |
IHC/IF/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Keratin, type I cytoskeletal 17 (300-432 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ABT-CK17 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: |
IHC-P 1:100-500WB 1:200-1000IF 1:100-500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KRT17 |
| Gene ID: |
3872 |
| Uniprot ID: |
K1C17_HUMAN |
| Immunogen Region: |
300-432 aa |
| Specificity: |
This antibody detects endogenous levels of human Cytokeratin 17. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section. The antib |
| Immunogen: |
Synthesized peptide derived from the human Cytokeratin 17 at the amino acid range 300-432 |
| Post Translational Modifications | Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization. |
| Function | Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. |
| Protein Name | Keratin - Type I Cytoskeletal 1739.1Cytokeratin-17Ck-17Keratin-17K17 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 17 antibodyAnti-39.1 antibodyAnti-Cytokeratin-17 antibodyAnti-Ck-17 antibodyAnti-Keratin-17 antibodyAnti-K17 antibodyAnti-KRT17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
