| Host: | Mouse |
| Applications: | IHC/IF/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Keratin, type II cytoskeletal 1 (200-300 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-300 WB 1:500-2000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KRT1 |
| Gene ID: | 3848 |
| Uniprot ID: | K2C1_HUMAN |
| Immunogen Region: | 200-300 aa |
| Specificity: | This antibody detects endogenous levels of human Cytokeratin 1 |
| Immunogen: | Synthesized peptide derived from the human Cytokeratin 1 at the amino acid range 200-300 |
| Post Translational Modifications | Undergoes deimination of some arginine residues (citrullination). |
| Function | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. |
| Protein Name | Keratin - Type Ii Cytoskeletal 1 67 Kda Cytokeratin Cytokeratin-1 Ck-1 Hair Alpha Protein Keratin-1 K1 Type-Ii Keratin Kb1 |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-6805567 Reactome: R-HSA-6809371 Reactome: R-HSA-9725554 |
| Cellular Localisation | Cell Membrane Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 1 antibody Anti-67 Kda Cytokeratin antibody Anti-Cytokeratin-1 antibody Anti-Ck-1 antibody Anti-Hair Alpha Protein antibody Anti-Keratin-1 antibody Anti-K1 antibody Anti-Type-Ii Keratin Kb1 antibody Anti-KRT1 antibody Anti-KRTA antibody |
Information sourced from Uniprot.org