Anti-KPNB1 antibody (STJA0007119)

SKU:
STJA0007119

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Importin subunit beta-1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KPNB1
Gene ID: 3837
Uniprot ID: IMB1_HUMAN
Specificity: This antibody detects endogenous levels of Importin Beta at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human Importin Beta
Function Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.
Protein Name Importin Subunit Beta-1
Importin-90
Karyopherin Subunit Beta-1
Nuclear Factor P97
Pore Targeting Complex 97 Kda Subunit
Ptac97
Database Links Reactome: R-HSA-1169408
Reactome: R-HSA-140342
Reactome: R-HSA-1655829
Reactome: R-HSA-168271
Reactome: R-HSA-168276
Reactome: R-HSA-180746
Reactome: R-HSA-2995383
Reactome: R-HSA-6798695
Reactome: R-HSA-68616
Reactome: R-HSA-909733
Reactome: R-HSA-9615933
Reactome: R-HSA-9636249
Reactome: R-HSA-9692916
Cellular Localisation Cytoplasm
Nucleus Envelope
Alternative Antibody Names Anti-Importin Subunit Beta-1 antibody
Anti-Importin-90 antibody
Anti-Karyopherin Subunit Beta-1 antibody
Anti-Nuclear Factor P97 antibody
Anti-Pore Targeting Complex 97 Kda Subunit antibody
Anti-Ptac97 antibody
Anti-KPNB1 antibody
Anti-NTF97 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance