| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KPNA5 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KPNA5 |
| Gene ID: |
3841 |
| Uniprot ID: |
IMA6_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human KPNA5 (NP_002260.2). |
| Immunogen Sequence: |
MDAMASPGKDNYRMKSYKNK ALNPQEMRRRREEEGIQLRK QKREEQLFKRRNVYLPRNDE SMLESPIQDPDISSTVPIPE EEVVTTDMVQMIFSNNADQQ LTATQKFRKLLSKEPNPPID QVIQKPGVVQRFVKFLERNE NCTLQFEAAWALTNIASGTF LHTKVVIETGAVPIFIKLLN SEHEDVQEQAVWALGNIAGD NAECRDFVLNCEILPPLLEL LTNSNRLTTTRNAVWALSN |
| Tissue Specificity | Testis. |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. |
| Protein Name | Importin Subunit Alpha-6Karyopherin Subunit Alpha-5 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-168276 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Importin Subunit Alpha-6 antibodyAnti-Karyopherin Subunit Alpha-5 antibodyAnti-KPNA5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
