| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLRB1 |
| Gene ID: | 3820 |
| Uniprot ID: | KLRB1_HUMAN |
| Immunogen Region: | 73-140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 73-140 of human KLRB1 (NP_002249.1). |
| Immunogen Sequence: | KCSVDIQQSRNKTTERPGLL NCPIYWQQLREKCLLFSHTV NPWNNSLADCSTKESSLLLI RDKDELIH |
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily B Member 1 C-Type Lectin Domain Family 5 Member B Hnkr-P1a Nkr-P1a Natural Killer Cell Surface Protein P1a Cd Antigen Cd161 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Lectin-Like Receptor Subfamily B Member 1 antibody Anti-C-Type Lectin Domain Family 5 Member B antibody Anti-Hnkr-P1a antibody Anti-Nkr-P1a antibody Anti-Natural Killer Cell Surface Protein P1a antibody Anti-Cd Antigen Cd161 antibody Anti-KLRB1 antibody Anti-CLEC5B antibody Anti-NKRP1A antibody |
Information sourced from Uniprot.org