| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLHL15 |
| Gene ID: | 80311 |
| Uniprot ID: | KLH15_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human KLHL15 (NP_085127.2). |
| Immunogen Sequence: | MAGDVEGFCSSIHDTSVSAG FRALYEEGLLLDVTLVIEDH QFQAHKALLATQSDYFRIMF TADMRERDQDKIHLKGLTAT GFSHVLQFMYYGTIELSMNT VHEILQAAMYVQLIEVVKFC CSFLLAKICLENCAEIMRLL DDFGVNIEGVREKLDTFLLD NFVPLMSRPDFLSYLSFEKL MSYLDNDHLSRFPEIELYEA VQSWLRHDRRRWRHTDTIIQ NIRFCLMTPTSVFEKVKTS |
| Function | Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR). |
| Protein Name | Kelch-Like Protein 15 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Kelch-Like Protein 15 antibodyAnti-KLHL15 antibodyAnti-KIAA1677 antibody |
Information sourced from Uniprot.org
