| Tissue Specificity | Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes. |
| Post Translational Modifications | Autoubiquitinated by the CRL2(KLHDC2) E3 ligase complex. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding. |
| Protein Name | Kelch Domain-Containing Protein 2Hepatocellular Carcinoma-Associated Antigen 33Host Cell Factor Homolog LcpHost Cell Factor-Like Protein 1Hclp-1 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Kelch Domain-Containing Protein 2 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 33 antibodyAnti-Host Cell Factor Homolog Lcp antibodyAnti-Host Cell Factor-Like Protein 1 antibodyAnti-Hclp-1 antibodyAnti-KLHDC2 antibodyAnti-HCA33 antibody |
Information sourced from Uniprot.org
