| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLF8 |
| Gene ID: | 11279 |
| Uniprot ID: | KLF8_HUMAN |
| Immunogen Region: | 210-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human KLF8 (NP_009181.2). |
| Immunogen Sequence: | GKNAGSVKVDPTSMSPLEIP SDSEESTIESGSSALQSLQG LQQEPAAMAQMQGEESLDLK RRRIHQCDFAG |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location. |
| Function | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). |
| Protein Name | Krueppel-Like Factor 8Basic Krueppel-Like Factor 3Zinc Finger Protein 741 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 8 antibodyAnti-Basic Krueppel-Like Factor 3 antibodyAnti-Zinc Finger Protein 741 antibodyAnti-KLF8 antibodyAnti-BKLF3 antibodyAnti-ZNF741 antibody |
Information sourced from Uniprot.org