| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Krueppel-like factor 8 (191-240 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLF8 |
| Gene ID: | 11279 |
| Uniprot ID: | KLF8_HUMAN |
| Immunogen Region: | 191-240 aa |
| Specificity: | KLF8 Polyclonal Antibody detects endogenous levels of KLF8 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human KLF8 at the amino acid range 191-240 |
| Post Translational Modifications | Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location. |
| Function | Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). |
| Protein Name | Krueppel-Like Factor 8Basic Krueppel-Like Factor 3Zinc Finger Protein 741 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Krueppel-Like Factor 8 antibodyAnti-Basic Krueppel-Like Factor 3 antibodyAnti-Zinc Finger Protein 741 antibodyAnti-KLF8 antibodyAnti-BKLF3 antibodyAnti-ZNF741 antibody |
Information sourced from Uniprot.org