Anti-KLB antibody (720-990) (STJ118077)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLB (720-990) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLB |
| Gene ID | 152831 |
| Uniprot ID | KLOTB_HUMAN |
| Immunogen Region | 720-990 |
| Immunogen Sequence | ALAWRLYDRQFRPSQRGAVS LSLHADWAEPANPYADSHWR AAERFLQFEIAWFAEPLFKT GDYPAAMREYIASKHRRGLS SSALPRLTEAERRLLKGTVD FCALNHFTTRFVMHEQLAGS RYDSDRDIQFLQDITRLSSP TRLAVIPWGVRKLLRWVRRN YGDMDIYITASGIDDQALED DRLRKYYLGKYLQEVLKAYL IDKVRIKGYYAFKLAEEKSK PRFGFFTSDFKAKSSIQFY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 720-990 of human KLB (NP_783864.1). |
Additional Info
| Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. |
| Protein Name | Beta-KlothoBklBetaklothoKlotho Beta-Like Protein |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1307965Reactome: R-HSA-2219530Reactome: R-HSA-5654228Reactome: R-HSA-5654712Reactome: R-HSA-5654719Reactome: R-HSA-5654720Reactome: R-HSA-5654733Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-Klotho antibodyAnti-Bkl antibodyAnti-Betaklotho antibodyAnti-Klotho Beta-Like Protein antibodyAnti-KLB antibody |
Information sourced from Uniprot.org