| Host: | Goat |
| Applications: | Pep-ELISA |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-KIF5A (C-Term) is suitable for use in ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave bands at approx 140, 50, 35 and 20kDa in Human Brain lysates at 1ug of primary. Please note that currently we cannot find an explanation in the literature |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | KIF5A |
| Gene ID: | 3798 |
| Uniprot ID: | KIF5A_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_004975.2 |
| Immunogen Sequence: | QAKLFPLHQETAAS |
| Function | Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. |
| Protein Name | Kinesin Heavy Chain Isoform 5aKinesin Heavy Chain Neuron-Specific 1Neuronal Kinesin Heavy ChainNkhc |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-264876Reactome: R-HSA-5625970Reactome: R-HSA-6811434Reactome: R-HSA-983189 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonPerikaryonConcentrated In The Cell Body Of The NeuronsParticularly In The Perinuclear Region |
| Alternative Antibody Names | Anti-Kinesin Heavy Chain Isoform 5a antibodyAnti-Kinesin Heavy Chain Neuron-Specific 1 antibodyAnti-Neuronal Kinesin Heavy Chain antibodyAnti-Nkhc antibodyAnti-KIF5A antibodyAnti-NKHC1 antibody |
Information sourced from Uniprot.org